| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 14/05/22 17:30 | 14/05/22 17:30 | Espanyol Barcelona | FC Valencia | 1-1 | 2 - 4 points |
| 15/05/22 18:30 | 15/05/22 18:30 | Athletic Bilbao | CA Osasuna | 2-0 | 2 - 4 points |
| 15/05/22 18:30 | 15/05/22 18:30 | Atletico Madrid | FC Sevilla | 1-1 | 2 - 4 points |
| 15/05/22 18:30 | 15/05/22 18:30 | Real Betis Sevilla | FC Granada | 2-0 | 2 - 4 points |
| 15/05/22 18:30 | 15/05/22 18:30 | Celta Vigo | FC Elche | 1-0 | 2 - 4 points |
| 15/05/22 18:30 | 15/05/22 18:30 | RCD Mallorca | Rayo Vallecano | 2-1 | 2 - 4 points |
| 15/05/22 18:30 | 15/05/22 18:30 | FC Getafe | FC Barcelona | 0-0 | 2 - 4 points |
| 15/05/22 18:30 | 15/05/22 18:30 | FC Cadiz | Real Madrid | 1-1 | 2 - 4 points |
| 15/05/22 18:30 | 15/05/22 18:30 | UD Levante | Deportivo Alaves | 3-1 | 2 - 4 points |
| 15/05/22 18:30 | 15/05/22 18:30 | FC Villarreal | Real Sociedad | 1-2 | 2 - 4 points |