| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 10/05/22 18:00 | 10/05/22 18:00 | FC Valencia | Real Betis Sevilla | 0-3 | 2 - 4 points |
| 10/05/22 19:00 | 10/05/22 19:00 | FC Granada | Athletic Bilbao | 1-0 | 2 - 4 points |
| 10/05/22 20:30 | 10/05/22 20:30 | FC Barcelona | Celta Vigo | 3-1 | 2 - 4 points |
| 11/05/22 18:00 | 11/05/22 18:00 | Deportivo Alaves | Espanyol Barcelona | 2-1 | 2 - 4 points |
| 11/05/22 18:00 | 11/05/22 18:00 | CA Osasuna | FC Getafe | 1-1 | 2 - 4 points |
| 11/05/22 19:30 | 11/05/22 19:30 | FC Sevilla | RCD Mallorca | 0-0 | 2 - 4 points |
| 11/05/22 20:30 | 11/05/22 20:30 | FC Elche | Atletico Madrid | 0-2 | 2 - 4 points |
| 12/05/22 18:00 | 12/05/22 18:00 | Real Sociedad | FC Cadiz | 3-0 | 2 - 4 points |
| 12/05/22 19:00 | 12/05/22 19:00 | Rayo Vallecano | FC Villarreal | 1-5 | 2 - 4 points |
| 12/05/22 20:30 | 12/05/22 20:30 | Real Madrid | UD Levante | 6-0 | 2 - 4 points |