| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 06/05/22 20:00 | 06/05/22 20:00 | UD Levante | Real Sociedad | 2-1 | 2 - 4 points |
| 07/05/22 13:00 | 07/05/22 13:00 | RCD Mallorca | FC Granada | 2-6 | 2 - 4 points |
| 07/05/22 15:15 | 07/05/22 15:15 | Athletic Bilbao | FC Valencia | 0-0 | 2 - 4 points |
| 07/05/22 17:30 | 07/05/22 17:30 | FC Cadiz | FC Elche | 3-0 | 2 - 4 points |
| 07/05/22 17:30 | 07/05/22 17:30 | Celta Vigo | Deportivo Alaves | 4-0 | 2 - 4 points |
| 07/05/22 20:00 | 07/05/22 20:00 | Real Betis Sevilla | FC Barcelona | 1-2 | 2 - 4 points |
| 08/05/22 13:00 | 08/05/22 13:00 | FC Getafe | Rayo Vallecano | 0-0 | 2 - 4 points |
| 08/05/22 15:15 | 08/05/22 15:15 | FC Villarreal | FC Sevilla | 1-1 | 2 - 4 points |
| 08/05/22 17:30 | 08/05/22 17:30 | Espanyol Barcelona | CA Osasuna | 1-1 | 2 - 4 points |
| 08/05/22 20:00 | 08/05/22 20:00 | Atletico Madrid | Real Madrid | 1-0 | 2 - 4 points |