| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 29/04/22 20:00 | 29/04/22 20:00 | FC Sevilla | FC Cadiz | 1-1 | 2 - 4 points |
| 30/04/22 13:00 | 30/04/22 13:00 | Deportivo Alaves | FC Villarreal | 2-1 | 2 - 4 points |
| 30/04/22 15:15 | 30/04/22 15:15 | Real Madrid | Espanyol Barcelona | 4-0 | 2 - 4 points |
| 30/04/22 17:30 | 30/04/22 17:30 | FC Valencia | UD Levante | 1-1 | 2 - 4 points |
| 30/04/22 20:00 | 30/04/22 20:00 | Athletic Bilbao | Atletico Madrid | 2-0 | 2 - 4 points |
| 01/05/22 13:00 | 01/05/22 13:00 | FC Elche | CA Osasuna | 1-1 | 2 - 4 points |
| 01/05/22 15:15 | 01/05/22 15:15 | FC Granada | Celta Vigo | 1-1 | 2 - 4 points |
| 01/05/22 17:30 | 01/05/22 17:30 | Rayo Vallecano | Real Sociedad | 1-1 | 2 - 4 points |
| 01/05/22 20:00 | 01/05/22 20:00 | FC Barcelona | RCD Mallorca | 2-1 | 2 - 4 points |
| 02/05/22 20:00 | 02/05/22 20:00 | FC Getafe | Real Betis Sevilla | 0-0 | 2 - 4 points |