| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 19/04/22 18:00 | 19/04/22 18:00 | RCD Mallorca | Deportivo Alaves | 2-1 | 2 - 4 points |
| 19/04/22 20:00 | 19/04/22 20:00 | Real Betis Sevilla | FC Elche | 0-1 | 2 - 4 points |
| 19/04/22 20:30 | 19/04/22 20:30 | FC Villarreal | FC Valencia | 2-0 | 2 - 4 points |
| 20/04/22 18:00 | 20/04/22 18:00 | Atletico Madrid | FC Granada | 0-0 | 2 - 4 points |
| 20/04/22 19:00 | 20/04/22 19:00 | Celta Vigo | FC Getafe | 0-2 | 2 - 4 points |
| 20/04/22 20:30 | 20/04/22 20:30 | CA Osasuna | Real Madrid | 1-3 | 2 - 4 points |
| 21/04/22 18:00 | 21/04/22 18:00 | Espanyol Barcelona | Rayo Vallecano | 0-1 | 2 - 4 points |
| 21/04/22 18:00 | 21/04/22 18:00 | UD Levante | FC Sevilla | 2-3 | 2 - 4 points |
| 21/04/22 19:00 | 21/04/22 19:00 | FC Cadiz | Athletic Bilbao | 2-3 | 2 - 4 points |
| 21/04/22 20:30 | 21/04/22 20:30 | Real Sociedad | FC Barcelona | 0-1 | 2 - 4 points |