| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 15/04/22 20:00 | 15/04/22 20:00 | Real Sociedad | Real Betis Sevilla | 0-0 | 2 - 4 points |
| 16/04/22 13:00 | 16/04/22 13:00 | FC Elche | RCD Mallorca | 3-0 | 2 - 4 points |
| 16/04/22 15:15 | 16/04/22 15:15 | Deportivo Alaves | Rayo Vallecano | 1-0 | 2 - 4 points |
| 16/04/22 17:30 | 16/04/22 17:30 | FC Valencia | CA Osasuna | 1-2 | 2 - 4 points |
| 16/04/22 20:00 | 16/04/22 20:00 | FC Getafe | FC Villarreal | 1-2 | 2 - 4 points |
| 17/04/22 13:00 | 17/04/22 13:00 | FC Granada | UD Levante | 1-4 | 2 - 4 points |
| 17/04/22 15:15 | 17/04/22 15:15 | Atletico Madrid | Espanyol Barcelona | 2-1 | 2 - 4 points |
| 17/04/22 17:30 | 17/04/22 17:30 | Athletic Bilbao | Celta Vigo | 0-2 | 2 - 4 points |
| 17/04/22 20:00 | 17/04/22 20:00 | FC Sevilla | Real Madrid | 2-3 | 2 - 4 points |
| 18/04/22 20:00 | 18/04/22 20:00 | FC Barcelona | FC Cadiz | 0-1 | 2 - 4 points |