| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 08/04/22 20:00 | 08/04/22 20:00 | FC Sevilla | FC Granada | 4-2 | 2 - 4 points |
| 09/04/22 13:00 | 09/04/22 13:00 | FC Cadiz | Real Betis Sevilla | 1-2 | 2 - 4 points |
| 09/04/22 15:15 | 09/04/22 15:15 | RCD Mallorca | Atletico Madrid | 1-0 | 2 - 4 points |
| 09/04/22 17:30 | 09/04/22 17:30 | FC Villarreal | Athletic Bilbao | 1-1 | 2 - 4 points |
| 09/04/22 20:00 | 09/04/22 20:00 | Real Madrid | FC Getafe | 2-0 | 2 - 4 points |
| 10/04/22 13:00 | 10/04/22 13:00 | CA Osasuna | Deportivo Alaves | 1-0 | 2 - 4 points |
| 10/04/22 15:15 | 10/04/22 15:15 | Espanyol Barcelona | Celta Vigo | 1-0 | 2 - 4 points |
| 10/04/22 17:30 | 10/04/22 17:30 | FC Elche | Real Sociedad | 1-2 | 2 - 4 points |
| 10/04/22 20:00 | 10/04/22 20:00 | UD Levante | FC Barcelona | 2-3 | 2 - 4 points |
| 11/04/22 20:00 | 11/04/22 20:00 | Rayo Vallecano | FC Valencia | 1-1 | 2 - 4 points |