| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 02/04/22 13:00 | 02/04/22 13:00 | FC Getafe | RCD Mallorca | 1-0 | 2 - 4 points |
| 02/04/22 15:15 | 02/04/22 15:15 | UD Levante | FC Villarreal | 2-0 | 2 - 4 points |
| 02/04/22 17:30 | 02/04/22 17:30 | Celta Vigo | Real Madrid | 1-2 | 2 - 4 points |
| 02/04/22 20:00 | 02/04/22 20:00 | Atletico Madrid | Deportivo Alaves | 4-1 | 2 - 4 points |
| 03/04/22 13:00 | 03/04/22 13:00 | Athletic Bilbao | FC Elche | 2-1 | 2 - 4 points |
| 03/04/22 15:15 | 03/04/22 15:15 | Real Betis Sevilla | CA Osasuna | 4-1 | 2 - 4 points |
| 03/04/22 17:30 | 03/04/22 17:30 | FC Granada | Rayo Vallecano | 2-2 | 2 - 4 points |
| 03/04/22 17:30 | 03/04/22 17:30 | FC Valencia | FC Cadiz | 0-0 | 2 - 4 points |
| 03/04/22 20:00 | 03/04/22 20:00 | FC Barcelona | FC Sevilla | 1-0 | 2 - 4 points |
| 04/04/22 20:00 | 04/04/22 20:00 | Real Sociedad | Espanyol Barcelona | 1-0 | 2 - 4 points |