| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 27/08/21 19:00 | 27/08/21 19:00 | RCD Mallorca | Espanyol Barcelona | 1-0 | 2 - 4 points |
| 27/08/21 21:15 | 27/08/21 21:15 | FC Valencia | Deportivo Alaves | 3-0 | 2 - 4 points |
| 28/08/21 16:00 | 28/08/21 16:00 | Celta Vigo | Athletic Bilbao | 0-1 | 2 - 4 points |
| 28/08/21 18:30 | 28/08/21 18:30 | Real Sociedad | UD Levante | 1-0 | 2 - 4 points |
| 28/08/21 18:30 | 28/08/21 18:30 | FC Elche | FC Sevilla | 1-1 | 2 - 4 points |
| 28/08/21 21:00 | 28/08/21 21:00 | Real Betis Sevilla | Real Madrid | 0-1 | 2 - 4 points |
| 29/08/21 16:00 | 29/08/21 16:00 | FC Barcelona | FC Getafe | 2-1 | 2 - 4 points |
| 29/08/21 18:30 | 29/08/21 18:30 | Rayo Vallecano | FC Granada | 4-0 | 2 - 4 points |
| 29/08/21 18:30 | 29/08/21 18:30 | FC Cadiz | CA Osasuna | 2-3 | 2 - 4 points |
| 29/08/21 21:00 | 29/08/21 21:00 | Atletico Madrid | FC Villarreal | 2-2 | 2 - 4 points |