| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 18/03/22 20:00 | 18/03/22 20:00 | Athletic Bilbao | FC Getafe | 1-1 | 2 - 4 points |
| 19/03/22 13:00 | 19/03/22 13:00 | Deportivo Alaves | FC Granada | 2-3 | 2 - 4 points |
| 19/03/22 15:15 | 19/03/22 15:15 | FC Elche | FC Valencia | 0-1 | 2 - 4 points |
| 19/03/22 17:30 | 19/03/22 17:30 | CA Osasuna | UD Levante | 3-1 | 2 - 4 points |
| 19/03/22 20:00 | 19/03/22 20:00 | Rayo Vallecano | Atletico Madrid | 0-1 | 2 - 4 points |
| 20/03/22 13:00 | 20/03/22 13:00 | Espanyol Barcelona | RCD Mallorca | 1-0 | 2 - 4 points |
| 20/03/22 15:15 | 20/03/22 15:15 | Celta Vigo | Real Betis Sevilla | 0-0 | 2 - 4 points |
| 20/03/22 15:15 | 20/03/22 15:15 | FC Cadiz | FC Villarreal | 1-0 | 2 - 4 points |
| 20/03/22 17:30 | 20/03/22 17:30 | FC Sevilla | Real Sociedad | 0-0 | 2 - 4 points |
| 20/03/22 20:00 | 20/03/22 20:00 | Real Madrid | FC Barcelona | 0-4 | 2 - 4 points |