| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 11/03/22 20:00 | 11/03/22 20:00 | Atletico Madrid | FC Cadiz | 2-1 | 2 - 4 points |
| 12/03/22 13:00 | 12/03/22 13:00 | UD Levante | Espanyol Barcelona | 1-1 | 2 - 4 points |
| 12/03/22 15:15 | 12/03/22 15:15 | FC Granada | FC Elche | 0-1 | 2 - 4 points |
| 12/03/22 17:30 | 12/03/22 17:30 | FC Villarreal | Celta Vigo | 1-0 | 2 - 4 points |
| 12/03/22 20:00 | 12/03/22 20:00 | FC Getafe | FC Valencia | 0-0 | 2 - 4 points |
| 13/03/22 13:00 | 13/03/22 13:00 | Rayo Vallecano | FC Sevilla | 1-1 | 2 - 4 points |
| 13/03/22 15:15 | 13/03/22 15:15 | Real Betis Sevilla | Athletic Bilbao | 1-0 | 2 - 4 points |
| 13/03/22 17:30 | 13/03/22 17:30 | Real Sociedad | Deportivo Alaves | 1-0 | 2 - 4 points |
| 13/03/22 20:00 | 13/03/22 20:00 | FC Barcelona | CA Osasuna | 4-0 | 2 - 4 points |
| 14/03/22 20:00 | 14/03/22 20:00 | RCD Mallorca | Real Madrid | 0-3 | 2 - 4 points |