| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 04/03/22 20:00 | 04/03/22 20:00 | Deportivo Alaves | FC Sevilla | 0-0 | 2 - 4 points |
| 05/03/22 13:00 | 05/03/22 13:00 | CA Osasuna | FC Villarreal | 1-0 | 2 - 4 points |
| 05/03/22 15:15 | 05/03/22 15:15 | Espanyol Barcelona | FC Getafe | 2-0 | 2 - 4 points |
| 05/03/22 17:30 | 05/03/22 17:30 | FC Valencia | FC Granada | 3-1 | 2 - 4 points |
| 05/03/22 20:00 | 05/03/22 20:00 | Real Madrid | Real Sociedad | 4-1 | 2 - 4 points |
| 06/03/22 13:00 | 06/03/22 13:00 | FC Cadiz | Rayo Vallecano | 2-0 | 2 - 4 points |
| 06/03/22 15:15 | 06/03/22 15:15 | FC Elche | FC Barcelona | 1-2 | 2 - 4 points |
| 06/03/22 17:30 | 06/03/22 17:30 | Celta Vigo | RCD Mallorca | 4-3 | 2 - 4 points |
| 06/03/22 20:00 | 06/03/22 20:00 | Real Betis Sevilla | Atletico Madrid | 1-3 | 2 - 4 points |
| 07/03/22 20:00 | 07/03/22 20:00 | Athletic Bilbao | UD Levante | 3-1 | 2 - 4 points |