| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 25/02/22 20:00 | 25/02/22 20:00 | UD Levante | FC Elche | 3-0 | 2 - 4 points |
| 26/02/22 13:00 | 26/02/22 13:00 | RCD Mallorca | FC Valencia | 0-1 | 2 - 4 points |
| 26/02/22 15:15 | 26/02/22 15:15 | FC Getafe | Deportivo Alaves | 2-2 | 2 - 4 points |
| 26/02/22 17:30 | 26/02/22 17:30 | Rayo Vallecano | Real Madrid | 0-1 | 2 - 4 points |
| 26/02/22 20:00 | 26/02/22 20:00 | Atletico Madrid | Celta Vigo | 2-0 | 2 - 4 points |
| 27/02/22 13:00 | 27/02/22 13:00 | FC Villarreal | Espanyol Barcelona | 5-1 | 2 - 4 points |
| 27/02/22 15:15 | 27/02/22 15:15 | FC Sevilla | Real Betis Sevilla | 2-1 | 2 - 4 points |
| 27/02/22 17:30 | 27/02/22 17:30 | Real Sociedad | CA Osasuna | 1-0 | 2 - 4 points |
| 27/02/22 20:00 | 27/02/22 20:00 | FC Barcelona | Athletic Bilbao | 4-0 | 2 - 4 points |
| 28/02/22 20:00 | 28/02/22 20:00 | FC Granada | FC Cadiz | 0-0 | 2 - 4 points |