| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 18/02/22 20:00 | 18/02/22 20:00 | FC Elche | Rayo Vallecano | 2-1 | 2 - 4 points |
| 19/02/22 13:00 | 19/02/22 13:00 | FC Granada | FC Villarreal | 1-4 | 2 - 4 points |
| 19/02/22 15:15 | 19/02/22 15:15 | CA Osasuna | Atletico Madrid | 0-3 | 2 - 4 points |
| 19/02/22 17:30 | 19/02/22 17:30 | FC Cadiz | FC Getafe | 1-1 | 2 - 4 points |
| 19/02/22 20:00 | 19/02/22 20:00 | Real Madrid | Deportivo Alaves | 3-0 | 2 - 4 points |
| 20/02/22 13:00 | 20/02/22 13:00 | Espanyol Barcelona | FC Sevilla | 1-1 | 2 - 4 points |
| 20/02/22 15:15 | 20/02/22 15:15 | FC Valencia | FC Barcelona | 1-4 | 2 - 4 points |
| 20/02/22 17:30 | 20/02/22 17:30 | Real Betis Sevilla | RCD Mallorca | 2-1 | 2 - 4 points |
| 20/02/22 20:00 | 20/02/22 20:00 | Athletic Bilbao | Real Sociedad | 4-0 | 2 - 4 points |
| 21/02/22 20:00 | 21/02/22 20:00 | Celta Vigo | UD Levante | 1-1 | 2 - 4 points |