| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 11/02/22 20:00 | 11/02/22 20:00 | FC Sevilla | FC Elche | 2-0 | 2 - 4 points |
| 12/02/22 13:00 | 12/02/22 13:00 | FC Cadiz | Celta Vigo | 0-0 | 2 - 4 points |
| 12/02/22 15:15 | 12/02/22 15:15 | FC Villarreal | Real Madrid | 0-0 | 2 - 4 points |
| 12/02/22 17:30 | 12/02/22 17:30 | Rayo Vallecano | CA Osasuna | 0-3 | 2 - 4 points |
| 12/02/22 20:00 | 12/02/22 20:00 | Atletico Madrid | FC Getafe | 4-3 | 2 - 4 points |
| 13/02/22 13:00 | 13/02/22 13:00 | Deportivo Alaves | FC Valencia | 2-1 | 2 - 4 points |
| 13/02/22 15:15 | 13/02/22 15:15 | UD Levante | Real Betis Sevilla | 2-4 | 2 - 4 points |
| 13/02/22 17:30 | 13/02/22 17:30 | Real Sociedad | FC Granada | 2-0 | 2 - 4 points |
| 13/02/22 20:00 | 13/02/22 20:00 | Espanyol Barcelona | FC Barcelona | 2-2 | 2 - 4 points |
| 14/02/22 20:00 | 14/02/22 20:00 | RCD Mallorca | Athletic Bilbao | 3-2 | 2 - 4 points |