| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 04/02/22 20:00 | 04/02/22 20:00 | FC Getafe | UD Levante | 3-0 | 2 - 4 points |
| 05/02/22 13:00 | 05/02/22 13:00 | FC Elche | Deportivo Alaves | 3-1 | 2 - 4 points |
| 05/02/22 15:15 | 05/02/22 15:15 | RCD Mallorca | FC Cadiz | 2-1 | 2 - 4 points |
| 05/02/22 17:30 | 05/02/22 17:30 | Celta Vigo | Rayo Vallecano | 2-0 | 2 - 4 points |
| 05/02/22 20:00 | 05/02/22 20:00 | CA Osasuna | FC Sevilla | 0-0 | 2 - 4 points |
| 06/02/22 13:00 | 06/02/22 13:00 | FC Valencia | Real Sociedad | 0-0 | 2 - 4 points |
| 06/02/22 15:15 | 06/02/22 15:15 | FC Barcelona | Atletico Madrid | 4-2 | 2 - 4 points |
| 06/02/22 17:30 | 06/02/22 17:30 | Real Betis Sevilla | FC Villarreal | 0-2 | 2 - 4 points |
| 06/02/22 20:00 | 06/02/22 20:00 | Real Madrid | FC Granada | 1-0 | 2 - 4 points |
| 07/02/22 20:00 | 07/02/22 20:00 | Athletic Bilbao | Espanyol Barcelona | 2-1 | 2 - 4 points |