| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 21/01/22 20:00 | 21/01/22 20:00 | Espanyol Barcelona | Real Betis Sevilla | 1-4 | 2 - 4 points |
| 22/01/22 13:00 | 22/01/22 13:00 | UD Levante | FC Cadiz | 0-2 | 2 - 4 points |
| 22/01/22 15:15 | 22/01/22 15:15 | FC Villarreal | RCD Mallorca | 3-0 | 2 - 4 points |
| 22/01/22 17:30 | 22/01/22 17:30 | FC Sevilla | Celta Vigo | 2-2 | 2 - 4 points |
| 22/01/22 20:00 | 22/01/22 20:00 | Atletico Madrid | FC Valencia | 3-2 | 2 - 4 points |
| 23/01/22 13:00 | 23/01/22 13:00 | FC Granada | CA Osasuna | 0-2 | 2 - 4 points |
| 23/01/22 15:15 | 23/01/22 15:15 | Real Madrid | FC Elche | 2-2 | 2 - 4 points |
| 23/01/22 17:30 | 23/01/22 17:30 | Rayo Vallecano | Athletic Bilbao | 0-1 | 2 - 4 points |
| 23/01/22 17:30 | 23/01/22 17:30 | Real Sociedad | FC Getafe | 0-0 | 2 - 4 points |
| 23/01/22 20:00 | 23/01/22 20:00 | Deportivo Alaves | FC Barcelona | 0-1 | 2 - 4 points |