| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 22/12/21 20:30 | 22/12/21 20:30 | Athletic Bilbao | Real Madrid | 1-2 | 2 - 4 points |
| 16/01/22 13:00 | 16/01/22 13:00 | FC Elche | FC Villarreal | 1-0 | 2 - 4 points |
| 18/01/22 19:00 | 18/01/22 19:00 | Real Betis Sevilla | Deportivo Alaves | 4-0 | 2 - 4 points |
| 18/01/22 20:30 | 18/01/22 20:30 | FC Cadiz | Espanyol Barcelona | 2-2 | 2 - 4 points |
| 19/01/22 18:00 | 19/01/22 18:00 | Celta Vigo | CA Osasuna | 2-0 | 2 - 4 points |
| 19/01/22 20:30 | 19/01/22 20:30 | FC Valencia | FC Sevilla | 1-1 | 2 - 4 points |
| 20/01/22 18:00 | 20/01/22 18:00 | FC Getafe | FC Granada | 4-2 | 2 - 4 points |
| 16/02/22 18:00 | 16/02/22 18:00 | Atletico Madrid | UD Levante | 0-1 | 2 - 4 points |
| 02/03/22 20:00 | 02/03/22 20:00 | RCD Mallorca | Real Sociedad | 0-2 | 2 - 4 points |
| 24/04/22 20:00 | 24/04/22 20:00 | FC Barcelona | Rayo Vallecano | 0-1 | 2 - 4 points |