| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 08/01/22 13:00 | 08/01/22 13:00 | UD Levante | RCD Mallorca | 2-0 | 2 - 4 points |
| 08/01/22 15:15 | 08/01/22 15:15 | Real Sociedad | Celta Vigo | 1-0 | 2 - 4 points |
| 08/01/22 17:30 | 08/01/22 17:30 | FC Granada | FC Barcelona | 1-1 | 2 - 4 points |
| 08/01/22 20:00 | 08/01/22 20:00 | Real Madrid | FC Valencia | 4-1 | 2 - 4 points |
| 09/01/22 13:00 | 09/01/22 13:00 | Rayo Vallecano | Real Betis Sevilla | 1-1 | 2 - 4 points |
| 09/01/22 15:15 | 09/01/22 15:15 | FC Sevilla | FC Getafe | 1-0 | 2 - 4 points |
| 09/01/22 17:30 | 09/01/22 17:30 | CA Osasuna | FC Cadiz | 2-0 | 2 - 4 points |
| 09/01/22 17:30 | 09/01/22 17:30 | Deportivo Alaves | Athletic Bilbao | 0-0 | 2 - 4 points |
| 09/01/22 20:00 | 09/01/22 20:00 | FC Villarreal | Atletico Madrid | 2-2 | 2 - 4 points |
| 10/01/22 20:00 | 10/01/22 20:00 | Espanyol Barcelona | FC Elche | 1-2 | 2 - 4 points |