| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 20/08/21 20:00 | 20/08/21 20:00 | Real Betis Sevilla | FC Cadiz | 1-1 | 2 - 4 points |
| 21/08/21 16:00 | 21/08/21 16:00 | Deportivo Alaves | RCD Mallorca | 0-1 | 2 - 4 points |
| 21/08/21 18:30 | 21/08/21 18:30 | FC Granada | FC Valencia | 1-1 | 2 - 4 points |
| 21/08/21 18:30 | 21/08/21 18:30 | Espanyol Barcelona | FC Villarreal | 0-0 | 2 - 4 points |
| 21/08/21 21:00 | 21/08/21 21:00 | Athletic Bilbao | FC Barcelona | 1-1 | 2 - 4 points |
| 22/08/21 16:00 | 22/08/21 16:00 | Real Sociedad | Rayo Vallecano | 1-0 | 2 - 4 points |
| 22/08/21 18:30 | 22/08/21 18:30 | Atletico Madrid | FC Elche | 1-0 | 2 - 4 points |
| 22/08/21 21:00 | 22/08/21 21:00 | UD Levante | Real Madrid | 3-3 | 2 - 4 points |
| 23/08/21 19:00 | 23/08/21 19:00 | FC Getafe | FC Sevilla | 0-1 | 2 - 4 points |
| 23/08/21 21:00 | 23/08/21 21:00 | CA Osasuna | Celta Vigo | 0-0 | 2 - 4 points |