| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 31/12/21 15:15 | 31/12/21 15:15 | FC Valencia | Espanyol Barcelona | 1-2 | 2 - 4 points |
| 02/01/22 13:00 | 02/01/22 13:00 | FC Getafe | Real Madrid | 1-0 | 2 - 4 points |
| 02/01/22 15:15 | 02/01/22 15:15 | Atletico Madrid | Rayo Vallecano | 2-0 | 2 - 4 points |
| 02/01/22 15:15 | 02/01/22 15:15 | FC Elche | FC Granada | 0-0 | 2 - 4 points |
| 02/01/22 17:30 | 02/01/22 17:30 | Deportivo Alaves | Real Sociedad | 1-1 | 2 - 4 points |
| 02/01/22 17:30 | 02/01/22 17:30 | Real Betis Sevilla | Celta Vigo | 0-2 | 2 - 4 points |
| 02/01/22 20:00 | 02/01/22 20:00 | RCD Mallorca | FC Barcelona | 0-1 | 2 - 4 points |
| 03/01/22 18:00 | 03/01/22 18:00 | FC Villarreal | UD Levante | 5-0 | 2 - 4 points |
| 03/01/22 20:05 | 03/01/22 20:05 | CA Osasuna | Athletic Bilbao | 1-3 | 2 - 4 points |
| 03/01/22 20:15 | 03/01/22 20:15 | FC Cadiz | FC Sevilla | 0-1 | 2 - 4 points |