| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 17/12/21 20:00 | 17/12/21 20:00 | Celta Vigo | Espanyol Barcelona | 3-1 | 2 - 4 points |
| 18/12/21 13:00 | 18/12/21 13:00 | Rayo Vallecano | Deportivo Alaves | 2-0 | 2 - 4 points |
| 18/12/21 15:15 | 18/12/21 15:15 | Real Sociedad | FC Villarreal | 1-3 | 2 - 4 points |
| 18/12/21 17:30 | 18/12/21 17:30 | FC Barcelona | FC Elche | 3-2 | 2 - 4 points |
| 18/12/21 20:00 | 18/12/21 20:00 | FC Sevilla | Atletico Madrid | 2-1 | 2 - 4 points |
| 19/12/21 13:00 | 19/12/21 13:00 | FC Granada | RCD Mallorca | 4-1 | 2 - 4 points |
| 19/12/21 15:15 | 19/12/21 15:15 | Athletic Bilbao | Real Betis Sevilla | 3-2 | 2 - 4 points |
| 19/12/21 17:30 | 19/12/21 17:30 | FC Getafe | CA Osasuna | 1-0 | 2 - 4 points |
| 19/12/21 20:00 | 19/12/21 20:00 | Real Madrid | FC Cadiz | 0-0 | 2 - 4 points |
| 20/12/21 20:00 | 20/12/21 20:00 | UD Levante | FC Valencia | 3-4 | 2 - 4 points |