| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 03/12/21 20:00 | 03/12/21 20:00 | FC Granada | Deportivo Alaves | 2-1 | 2 - 4 points |
| 04/12/21 13:00 | 04/12/21 13:00 | FC Sevilla | FC Villarreal | 1-0 | 2 - 4 points |
| 04/12/21 15:15 | 04/12/21 15:15 | FC Barcelona | Real Betis Sevilla | 0-1 | 2 - 4 points |
| 04/12/21 17:30 | 04/12/21 17:30 | Atletico Madrid | RCD Mallorca | 1-2 | 2 - 4 points |
| 04/12/21 20:00 | 04/12/21 20:00 | Real Sociedad | Real Madrid | 0-2 | 2 - 4 points |
| 05/12/21 13:00 | 05/12/21 13:00 | Rayo Vallecano | Espanyol Barcelona | 1-0 | 2 - 4 points |
| 05/12/21 15:15 | 05/12/21 15:15 | FC Elche | FC Cadiz | 3-1 | 2 - 4 points |
| 05/12/21 17:30 | 05/12/21 17:30 | UD Levante | CA Osasuna | 0-0 | 2 - 4 points |
| 05/12/21 20:00 | 05/12/21 20:00 | Celta Vigo | FC Valencia | 1-2 | 2 - 4 points |
| 06/12/21 20:00 | 06/12/21 20:00 | FC Getafe | Athletic Bilbao | 0-0 | 2 - 4 points |