| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 26/11/21 20:00 | 26/11/21 20:00 | Athletic Bilbao | FC Granada | 2-2 | 2 - 4 points |
| 27/11/21 13:00 | 27/11/21 13:00 | Deportivo Alaves | Celta Vigo | 1-2 | 2 - 4 points |
| 27/11/21 15:15 | 27/11/21 15:15 | FC Valencia | Rayo Vallecano | 1-1 | 2 - 4 points |
| 27/11/21 17:30 | 27/11/21 17:30 | RCD Mallorca | FC Getafe | 0-0 | 2 - 4 points |
| 27/11/21 20:00 | 27/11/21 20:00 | FC Villarreal | FC Barcelona | 1-3 | 2 - 4 points |
| 28/11/21 13:00 | 28/11/21 13:00 | Real Betis Sevilla | UD Levante | 3-1 | 2 - 4 points |
| 28/11/21 15:15 | 28/11/21 15:15 | Espanyol Barcelona | Real Sociedad | 1-0 | 2 - 4 points |
| 28/11/21 17:30 | 28/11/21 17:30 | FC Cadiz | Atletico Madrid | 1-4 | 2 - 4 points |
| 28/11/21 20:00 | 28/11/21 20:00 | Real Madrid | FC Sevilla | 2-1 | 2 - 4 points |
| 29/11/21 20:00 | 29/11/21 20:00 | CA Osasuna | FC Elche | 1-1 | 2 - 4 points |