| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 19/11/21 20:00 | 19/11/21 20:00 | UD Levante | Athletic Bilbao | 0-0 | 2 - 4 points |
| 20/11/21 13:00 | 20/11/21 13:00 | Celta Vigo | FC Villarreal | 1-1 | 2 - 4 points |
| 20/11/21 15:15 | 20/11/21 15:15 | FC Sevilla | Deportivo Alaves | 2-2 | 2 - 4 points |
| 20/11/21 17:30 | 20/11/21 17:30 | Atletico Madrid | CA Osasuna | 1-0 | 2 - 4 points |
| 20/11/21 20:00 | 20/11/21 20:00 | FC Barcelona | Espanyol Barcelona | 1-0 | 2 - 4 points |
| 21/11/21 13:00 | 21/11/21 13:00 | FC Getafe | FC Cadiz | 4-0 | 2 - 4 points |
| 21/11/21 15:15 | 21/11/21 15:15 | FC Granada | Real Madrid | 1-4 | 2 - 4 points |
| 21/11/21 17:30 | 21/11/21 17:30 | FC Elche | Real Betis Sevilla | 0-3 | 2 - 4 points |
| 21/11/21 20:00 | 21/11/21 20:00 | Real Sociedad | FC Valencia | 0-0 | 2 - 4 points |
| 22/11/21 20:00 | 22/11/21 20:00 | Rayo Vallecano | RCD Mallorca | 3-1 | 2 - 4 points |