| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 05/11/21 20:00 | 05/11/21 20:00 | Athletic Bilbao | FC Cadiz | 0-1 | 2 - 4 points |
| 06/11/21 13:00 | 06/11/21 13:00 | Espanyol Barcelona | FC Granada | 2-0 | 2 - 4 points |
| 06/11/21 15:15 | 06/11/21 15:15 | Celta Vigo | FC Barcelona | 3-3 | 2 - 4 points |
| 06/11/21 17:30 | 06/11/21 17:30 | Deportivo Alaves | UD Levante | 2-1 | 2 - 4 points |
| 06/11/21 20:00 | 06/11/21 20:00 | Real Madrid | Rayo Vallecano | 2-1 | 2 - 4 points |
| 07/11/21 13:00 | 07/11/21 13:00 | FC Villarreal | FC Getafe | 1-0 | 2 - 4 points |
| 07/11/21 15:15 | 07/11/21 15:15 | FC Valencia | Atletico Madrid | 3-3 | 2 - 4 points |
| 07/11/21 17:30 | 07/11/21 17:30 | CA Osasuna | Real Sociedad | 0-2 | 2 - 4 points |
| 07/11/21 17:30 | 07/11/21 17:30 | RCD Mallorca | FC Elche | 2-2 | 2 - 4 points |
| 07/11/21 20:00 | 07/11/21 20:00 | Real Betis Sevilla | FC Sevilla | 0-2 | 2 - 4 points |