| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 30/10/21 13:00 | 30/10/21 13:00 | FC Elche | Real Madrid | 1-2 | 2 - 4 points |
| 30/10/21 15:15 | 30/10/21 15:15 | FC Sevilla | CA Osasuna | 2-0 | 2 - 4 points |
| 30/10/21 17:30 | 30/10/21 17:30 | FC Valencia | FC Villarreal | 2-0 | 2 - 4 points |
| 30/10/21 20:00 | 30/10/21 20:00 | FC Barcelona | Deportivo Alaves | 1-1 | 2 - 4 points |
| 31/10/21 13:00 | 31/10/21 13:00 | FC Cadiz | RCD Mallorca | 1-1 | 2 - 4 points |
| 31/10/21 15:15 | 31/10/21 15:15 | Atletico Madrid | Real Betis Sevilla | 3-0 | 2 - 4 points |
| 31/10/21 17:30 | 31/10/21 17:30 | FC Getafe | Espanyol Barcelona | 2-1 | 2 - 4 points |
| 31/10/21 20:00 | 31/10/21 20:00 | Real Sociedad | Athletic Bilbao | 1-1 | 2 - 4 points |
| 01/11/21 17:30 | 01/11/21 17:30 | Rayo Vallecano | Celta Vigo | 0-0 | 2 - 4 points |
| 01/11/21 20:00 | 01/11/21 20:00 | UD Levante | FC Granada | 0-3 | 2 - 4 points |