| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 26/10/21 18:00 | 26/10/21 18:00 | Deportivo Alaves | FC Elche | 1-0 | 2 - 4 points |
| 26/10/21 20:00 | 26/10/21 20:00 | Espanyol Barcelona | Athletic Bilbao | 1-1 | 2 - 4 points |
| 26/10/21 20:30 | 26/10/21 20:30 | FC Villarreal | FC Cadiz | 3-3 | 2 - 4 points |
| 27/10/21 18:00 | 27/10/21 18:00 | Rayo Vallecano | FC Barcelona | 1-0 | 2 - 4 points |
| 27/10/21 18:00 | 27/10/21 18:00 | RCD Mallorca | FC Sevilla | 1-1 | 2 - 4 points |
| 27/10/21 19:00 | 27/10/21 19:00 | Real Betis Sevilla | FC Valencia | 4-1 | 2 - 4 points |
| 27/10/21 20:30 | 27/10/21 20:30 | Real Madrid | CA Osasuna | 0-0 | 2 - 4 points |
| 28/10/21 18:00 | 28/10/21 18:00 | Celta Vigo | Real Sociedad | 0-2 | 2 - 4 points |
| 28/10/21 19:00 | 28/10/21 19:00 | FC Granada | FC Getafe | 1-1 | 2 - 4 points |
| 28/10/21 20:30 | 28/10/21 20:30 | UD Levante | Atletico Madrid | 2-2 | 2 - 4 points |