| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 22/10/21 20:00 | 22/10/21 20:00 | CA Osasuna | FC Granada | 1-1 | 2 - 4 points |
| 23/10/21 13:00 | 23/10/21 13:00 | FC Valencia | RCD Mallorca | 2-2 | 2 - 4 points |
| 23/10/21 15:15 | 23/10/21 15:15 | FC Cadiz | Deportivo Alaves | 0-2 | 2 - 4 points |
| 23/10/21 17:30 | 23/10/21 17:30 | FC Elche | Espanyol Barcelona | 2-2 | 2 - 4 points |
| 23/10/21 20:00 | 23/10/21 20:00 | Athletic Bilbao | FC Villarreal | 2-1 | 2 - 4 points |
| 24/10/21 13:00 | 24/10/21 13:00 | FC Sevilla | UD Levante | 5-3 | 2 - 4 points |
| 24/10/21 15:15 | 24/10/21 15:15 | FC Barcelona | Real Madrid | 1-2 | 2 - 4 points |
| 24/10/21 17:30 | 24/10/21 17:30 | Real Betis Sevilla | Rayo Vallecano | 3-2 | 2 - 4 points |
| 24/10/21 20:00 | 24/10/21 20:00 | Atletico Madrid | Real Sociedad | 2-2 | 2 - 4 points |
| 25/10/21 20:00 | 25/10/21 20:00 | FC Getafe | Celta Vigo | 0-3 | 2 - 4 points |