| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 13/08/21 20:00 | 13/08/21 20:00 | FC Valencia | FC Getafe | 1-0 | 2 - 4 points |
| 14/08/21 18:30 | 14/08/21 18:30 | FC Cadiz | UD Levante | 1-1 | 2 - 4 points |
| 14/08/21 18:30 | 14/08/21 18:30 | RCD Mallorca | Real Betis Sevilla | 1-1 | 2 - 4 points |
| 14/08/21 21:00 | 14/08/21 21:00 | CA Osasuna | Espanyol Barcelona | 0-0 | 2 - 4 points |
| 14/08/21 21:00 | 14/08/21 21:00 | Deportivo Alaves | Real Madrid | 1-4 | 2 - 4 points |
| 15/08/21 16:30 | 15/08/21 16:30 | Celta Vigo | Atletico Madrid | 1-2 | 2 - 4 points |
| 15/08/21 19:00 | 15/08/21 19:00 | FC Barcelona | Real Sociedad | 4-2 | 2 - 4 points |
| 15/08/21 21:15 | 15/08/21 21:15 | FC Sevilla | Rayo Vallecano | 3-0 | 2 - 4 points |
| 16/08/21 19:00 | 16/08/21 19:00 | FC Villarreal | FC Granada | 0-0 | 2 - 4 points |
| 16/08/21 21:00 | 16/08/21 21:00 | FC Elche | Athletic Bilbao | 0-0 | 2 - 4 points |