Schedule
| Date | Dead line | Home | Away | Group | Result | Points rule |
|---|---|---|---|---|---|---|
| 14/09/21 17:45 | 14/09/21 17:45 | FC Sevilla | FC Red Bull Salzburg | Group G | 1-1 | 3 - 8 - 10 |
| 14/09/21 17:45 | 14/09/21 17:45 | Young Boys Bern | Manchester United | Group F | 2-1 | 10 - 10 - 3 |
| 14/09/21 20:00 | 14/09/21 20:00 | Malmö FF | Juventus Turin | Group H | 0-3 | 10 - 8 - 3 |
| 14/09/21 20:00 | 14/09/21 20:00 | Chelsea FC | Zenit St. Petersburg | Group H | 1-0 | 3 - 10 - 10 |
| 14/09/21 20:00 | 14/09/21 20:00 | OSC Lille | VfL Wolfsburg | Group G | 0-0 | 6 - 4 - 5 |
| 14/09/21 20:00 | 14/09/21 20:00 | FC Barcelona | FC Bayern Munich | Group E | 0-3 | 9 - 7 - 4 |
| 14/09/21 20:00 | 14/09/21 20:00 | Dynamo Kiew | Benfica Lisbon | Group E | 0-0 | 7 - 5 - 4 |
| 14/09/21 20:00 | 14/09/21 20:00 | FC Villarreal | Atalanta Bergamo | Group F | 2-2 | 4 - 5 - 7 |
| 15/09/21 17:45 | 15/09/21 17:45 | Sheriff Tiraspol | Schachtjor Donezk | Group D | 2-0 | 10 - 9 - 3 |
| 15/09/21 17:45 | 15/09/21 17:45 | Besiktas Istanbul | Borussia Dortmund | Group C | 1-2 | 10 - 10 - 3 |
| 15/09/21 20:00 | 15/09/21 20:00 | Inter Milan | Real Madrid | Group D | 0-1 | 6 - 5 - 5 |
| 15/09/21 20:00 | 15/09/21 20:00 | Atletico Madrid | FC Porto | Group B | 0-0 | 3 - 9 - 10 |
| 15/09/21 20:00 | 15/09/21 20:00 | Liverpool FC | AC Milan | Group B | 3-2 | 3 - 6 - 10 |
| 15/09/21 20:00 | 15/09/21 20:00 | Club Brugge | Paris St. Germain | Group A | 1-1 | 10 - 10 - 3 |
| 15/09/21 20:00 | 15/09/21 20:00 | Manchester City | RB Leipzig | Group A | 6-3 | 3 - 10 - 10 |
| 15/09/21 20:00 | 15/09/21 20:00 | Sporting Lisbon | Ajax Amsterdam | Group C | 1-5 | 6 - 4 - 5 |