Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 09/03/22 17:45 | 09/03/22 17:45 | FC Porto | Olympique Lyon | 0-1 | 2 - 4 points |
| 09/03/22 17:45 | 09/03/22 17:45 | Real Betis Sevilla | Eintracht Frankfurt | 1-2 | 2 - 4 points |
| 10/03/22 17:45 | 10/03/22 17:45 | FC Sevilla | West Ham United | 1-0 | 2 - 4 points |
| 10/03/22 20:00 | 10/03/22 20:00 | FC Barcelona | Galatasaray Istanbul | 0-0 | 2 - 4 points |
| 10/03/22 20:00 | 10/03/22 20:00 | Sporting Braga | AS Monaco | 2-0 | 2 - 4 points |
| 10/03/22 20:00 | 10/03/22 20:00 | Glasgow Rangers | Red Star Belgrad | 3-0 | 2 - 4 points |
| 10/03/22 20:00 | 10/03/22 20:00 | Atalanta Bergamo | Bayer 04 Leverkusen | 3-2 | 2 - 4 points |