Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 24/02/22 17:45 | 24/02/22 17:45 | Olympiakos Piräus | Atalanta Bergamo | 0-3 | 2 - 4 points |
| 24/02/22 17:45 | 24/02/22 17:45 | Lazio Rom | FC Porto | 2-2 | 2 - 4 points |
| 24/02/22 17:45 | 24/02/22 17:45 | Real Sociedad | RB Leipzig | 1-3 | 2 - 4 points |
| 24/02/22 17:45 | 24/02/22 17:45 | Dinamo Zagreb | FC Sevilla | 1-0 | 2 - 4 points |
| 24/02/22 20:00 | 24/02/22 20:00 | Sporting Braga | Sheriff Tiraspol | 5-2a.PSO | 2 - 4 points |
| 24/02/22 20:00 | 24/02/22 20:00 | Glasgow Rangers | Borussia Dortmund | 2-2 | 2 - 4 points |
| 24/02/22 20:00 | 24/02/22 20:00 | SSC Napoli | FC Barcelona | 2-4 | 2 - 4 points |
| 24/02/22 20:00 | 24/02/22 20:00 | Real Betis Sevilla | Zenit St. Petersburg | 0-0 | 2 - 4 points |