Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 17/02/22 17:45 | 17/02/22 17:45 | Borussia Dortmund | Glasgow Rangers | 2-4 | 2 - 4 points |
| 17/02/22 17:45 | 17/02/22 17:45 | Zenit St. Petersburg | Real Betis Sevilla | 2-3 | 2 - 4 points |
| 17/02/22 17:45 | 17/02/22 17:45 | Sheriff Tiraspol | Sporting Braga | 2-0 | 2 - 4 points |
| 17/02/22 17:45 | 17/02/22 17:45 | FC Barcelona | SSC Napoli | 1-1 | 2 - 4 points |
| 17/02/22 20:00 | 17/02/22 20:00 | FC Porto | Lazio Rom | 2-1 | 2 - 4 points |
| 17/02/22 20:00 | 17/02/22 20:00 | Atalanta Bergamo | Olympiakos Piräus | 2-1 | 2 - 4 points |
| 17/02/22 20:00 | 17/02/22 20:00 | FC Sevilla | Dinamo Zagreb | 3-1 | 2 - 4 points |
| 17/02/22 20:00 | 17/02/22 20:00 | RB Leipzig | Real Sociedad | 2-2 | 2 - 4 points |