Schedule
| Date | Dead line | Home | Away | Group | Result | Points rule |
|---|---|---|---|---|---|---|
| 24/11/21 15:30 | 24/11/21 15:30 | Spartak Moscow | SSC Napoli | Group C | 2-1 | 2 - 4 points |
| 25/11/21 17:45 | 25/11/21 17:45 | SK Rapid Wien | West Ham United | Group H | 0-2 | 2 - 4 points |
| 25/11/21 17:45 | 25/11/21 17:45 | Dinamo Zagreb | KRC Genk | Group H | 1-1 | 2 - 4 points |
| 25/11/21 17:45 | 25/11/21 17:45 | Real Betis Sevilla | Ferencvaros Budapest | Group G | 2-0 | 2 - 4 points |
| 25/11/21 17:45 | 25/11/21 17:45 | Bayer 04 Leverkusen | Celtic Glasgow | Group G | 3-2 | 2 - 4 points |
| 25/11/21 17:45 | 25/11/21 17:45 | Galatasaray Istanbul | Olympique Marseille | Group E | 4-2 | 2 - 4 points |
| 25/11/21 17:45 | 25/11/21 17:45 | Lokomotive Moscow | Lazio Rom | Group E | 0-3 | 2 - 4 points |
| 25/11/21 17:45 | 25/11/21 17:45 | FC Midtjylland | Sporting Braga | Group F | 3-2 | 2 - 4 points |
| 25/11/21 17:45 | 25/11/21 17:45 | Red Star Belgrad | PFC Ludogorets Razgrad | Group F | 1-0 | 2 - 4 points |
| 25/11/21 20:00 | 25/11/21 20:00 | Leicester City | Legia Warschau | Group C | 3-1 | 2 - 4 points |
| 25/11/21 20:00 | 25/11/21 20:00 | AS Monaco | Real Sociedad | Group B | 2-1 | 2 - 4 points |
| 25/11/21 20:00 | 25/11/21 20:00 | PSV Eindhoven | SK Sturm Graz | Group B | 2-0 | 2 - 4 points |
| 25/11/21 20:00 | 25/11/21 20:00 | Eintracht Frankfurt | Royal Antwerp FC | Group D | 2-2 | 2 - 4 points |
| 25/11/21 20:00 | 25/11/21 20:00 | Olympiakos Piräus | Fenerbahce Istanbul | Group D | 1-0 | 2 - 4 points |
| 25/11/21 20:00 | 25/11/21 20:00 | Bröndby IF Copenhagen | Olympique Lyon | Group A | 1-3 | 2 - 4 points |
| 25/11/21 20:00 | 25/11/21 20:00 | Glasgow Rangers | Sparta Prag | Group A | 2-0 | 2 - 4 points |