Schedule
| Date | Dead line | Home | Away | Group | Result | Points rule |
|---|---|---|---|---|---|---|
| 04/11/21 17:45 | 04/11/21 17:45 | Legia Warschau | SSC Napoli | Group C | 1-4 | 2 - 4 points |
| 04/11/21 17:45 | 04/11/21 17:45 | KRC Genk | West Ham United | Group H | 2-2 | 2 - 4 points |
| 04/11/21 17:45 | 04/11/21 17:45 | Galatasaray Istanbul | Lokomotive Moscow | Group E | 1-1 | 2 - 4 points |
| 04/11/21 17:45 | 04/11/21 17:45 | AS Monaco | PSV Eindhoven | Group B | 0-0 | 2 - 4 points |
| 04/11/21 17:45 | 04/11/21 17:45 | Real Sociedad | SK Sturm Graz | Group B | 1-1 | 2 - 4 points |
| 04/11/21 17:45 | 04/11/21 17:45 | Olympiakos Piräus | Eintracht Frankfurt | Group D | 1-2 | 2 - 4 points |
| 04/11/21 17:45 | 04/11/21 17:45 | Bröndby IF Copenhagen | Glasgow Rangers | Group A | 1-1 | 2 - 4 points |
| 04/11/21 17:45 | 04/11/21 17:45 | Olympique Lyon | Sparta Prag | Group A | 3-0 | 2 - 4 points |
| 04/11/21 20:00 | 04/11/21 20:00 | Leicester City | Spartak Moscow | Group C | 1-1 | 2 - 4 points |
| 04/11/21 20:00 | 04/11/21 20:00 | Dinamo Zagreb | SK Rapid Wien | Group H | 3-1 | 2 - 4 points |
| 04/11/21 20:00 | 04/11/21 20:00 | Ferencvaros Budapest | Celtic Glasgow | Group G | 2-3 | 2 - 4 points |
| 04/11/21 20:00 | 04/11/21 20:00 | Bayer 04 Leverkusen | Real Betis Sevilla | Group G | 4-0 | 2 - 4 points |
| 04/11/21 20:00 | 04/11/21 20:00 | Olympique Marseille | Lazio Rom | Group E | 2-2 | 2 - 4 points |
| 04/11/21 20:00 | 04/11/21 20:00 | Red Star Belgrad | FC Midtjylland | Group F | 0-1 | 2 - 4 points |
| 04/11/21 20:00 | 04/11/21 20:00 | Sporting Braga | PFC Ludogorets Razgrad | Group F | 4-2 | 2 - 4 points |
| 04/11/21 20:00 | 04/11/21 20:00 | Royal Antwerp FC | Fenerbahce Istanbul | Group D | 0-3 | 2 - 4 points |