Schedule
| Date | Dead line | Home | Away | Group | Result | Points rule |
|---|---|---|---|---|---|---|
| 30/09/21 17:45 | 30/09/21 17:45 | Real Sociedad | AS Monaco | Group B | 1-1 | 2 - 4 points |
| 30/09/21 17:45 | 30/09/21 17:45 | SK Sturm Graz | PSV Eindhoven | Group B | 1-4 | 2 - 4 points |
| 30/09/21 17:45 | 30/09/21 17:45 | Fenerbahce Istanbul | Olympiakos Piräus | Group D | 0-3 | 2 - 4 points |
| 30/09/21 17:45 | 30/09/21 17:45 | Royal Antwerp FC | Eintracht Frankfurt | Group D | 0-1 | 2 - 4 points |
| 30/09/21 17:45 | 30/09/21 17:45 | Sparta Prag | Glasgow Rangers | Group A | 1-0 | 2 - 4 points |
| 30/09/21 17:45 | 30/09/21 17:45 | Olympique Lyon | Bröndby IF Copenhagen | Group A | 3-0 | 2 - 4 points |
| 30/09/21 17:45 | 30/09/21 17:45 | Legia Warschau | Leicester City | Group C | 1-0 | 2 - 4 points |
| 30/09/21 17:45 | 30/09/21 17:45 | SSC Napoli | Spartak Moscow | Group C | 2-3 | 2 - 4 points |
| 30/09/21 20:00 | 30/09/21 20:00 | KRC Genk | Dinamo Zagreb | Group H | 0-3 | 2 - 4 points |
| 30/09/21 20:00 | 30/09/21 20:00 | West Ham United | SK Rapid Wien | Group H | 2-0 | 2 - 4 points |
| 30/09/21 20:00 | 30/09/21 20:00 | Ferencvaros Budapest | Real Betis Sevilla | Group G | 1-3 | 2 - 4 points |
| 30/09/21 20:00 | 30/09/21 20:00 | Celtic Glasgow | Bayer 04 Leverkusen | Group G | 0-4 | 2 - 4 points |
| 30/09/21 20:00 | 30/09/21 20:00 | Lazio Rom | Lokomotive Moscow | Group E | 2-0 | 2 - 4 points |
| 30/09/21 20:00 | 30/09/21 20:00 | Olympique Marseille | Galatasaray Istanbul | Group E | 0-0 | 2 - 4 points |
| 30/09/21 20:00 | 30/09/21 20:00 | PFC Ludogorets Razgrad | Red Star Belgrad | Group F | 0-1 | 2 - 4 points |
| 30/09/21 20:00 | 30/09/21 20:00 | Sporting Braga | FC Midtjylland | Group F | 3-1 | 2 - 4 points |