Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 17/03/22 17:45 | 17/03/22 17:45 | Red Star Belgrad | Glasgow Rangers | 2-1 | 2 - 4 points |
| 17/03/22 17:45 | 17/03/22 17:45 | Galatasaray Istanbul | FC Barcelona | 1-2 | 2 - 4 points |
| 17/03/22 17:45 | 17/03/22 17:45 | AS Monaco | Sporting Braga | 1-1 | 2 - 4 points |
| 17/03/22 17:45 | 17/03/22 17:45 | Bayer 04 Leverkusen | Atalanta Bergamo | 0-1 | 2 - 4 points |
| 17/03/22 20:00 | 17/03/22 20:00 | West Ham United | FC Sevilla | 2-0a.e.t | 2 - 4 points |
| 17/03/22 20:00 | 17/03/22 20:00 | Olympique Lyon | FC Porto | 1-1 | 2 - 4 points |
| 17/03/22 20:00 | 17/03/22 20:00 | Eintracht Frankfurt | Real Betis Sevilla | 1-1a.e.t | 2 - 4 points |