| Date | Home | Away | Result |
|---|---|---|---|
| 13/02/25 17:45 | Royale Union Saint-Gilloise | Ajax Amsterdam | 0-2 |
| 13/02/25 17:45 | Fenerbahce Istanbul | RSC Anderlecht | 3-0 |
| 13/02/25 17:45 | FC Midtjylland | Real Sociedad | 1-2 |
| 13/02/25 17:45 | Ferencvaros Budapest | Viktoria Plzen | 1-0 |
| 13/02/25 20:00 | FC Porto | AS Roma | 1-1 |
| 13/02/25 20:00 | PAOK Saloniki | FCSB Bukarest | 1-2 |
| 13/02/25 20:00 | AZ Alkmaar | Galatasaray Istanbul | 4-1 |
| 13/02/25 20:00 | FC Twente Enschede | FK Bodö/Glimt | 2-1 |