| Date | Home | Away | Result |
|---|---|---|---|
| 30/01/25 20:00 | FCSB Bukarest | Manchester United | --- |
| 30/01/25 20:00 | RSC Anderlecht | 1899 Hoffenheim | --- |
| 30/01/25 20:00 | Athletic Bilbao | Viktoria Plzen | --- |
| 30/01/25 20:00 | OGC Nice | FK Bodö/Glimt | --- |
| 30/01/25 20:00 | Olympique Lyon | PFC Ludogorets Razgrad | --- |
| 30/01/25 20:00 | FC Midtjylland | Fenerbahce Istanbul | --- |
| 30/01/25 20:00 | Dynamo Kiew | Rigas Futbola Skola | --- |
| 30/01/25 20:00 | FC Twente Enschede | Besiktas Istanbul | --- |
| 30/01/25 20:00 | AS Roma | Eintracht Frankfurt | --- |
| 30/01/25 20:00 | Glasgow Rangers | Royale Union Saint-Gilloise | --- |
| 30/01/25 20:00 | Slavia Prag | Malmö FF | --- |
| 30/01/25 20:00 | Tottenham Hotspur | IF Elfsborg Boras | --- |
| 30/01/25 20:00 | Maccabi Tel Aviv | FC Porto | --- |
| 30/01/25 20:00 | Ajax Amsterdam | Galatasaray Istanbul | --- |
| 30/01/25 20:00 | Ferencvaros Budapest | AZ Alkmaar | --- |
| 30/01/25 20:00 | Sporting Braga | Lazio Rom | --- |
| 30/01/25 20:00 | Olympiakos Piräus | Qarabag | --- |
| 30/01/25 20:00 | Real Sociedad | PAOK Saloniki | --- |