| Date | Home | Away | Result |
|---|---|---|---|
| 30/01/25 20:00 | FCSB Bukarest | Manchester United | 0-2 |
| 30/01/25 20:00 | RSC Anderlecht | 1899 Hoffenheim | 3-4 |
| 30/01/25 20:00 | Athletic Bilbao | Viktoria Plzen | 3-1 |
| 30/01/25 20:00 | OGC Nice | FK Bodö/Glimt | 1-1 |
| 30/01/25 20:00 | Olympique Lyon | PFC Ludogorets Razgrad | 1-1 |
| 30/01/25 20:00 | FC Midtjylland | Fenerbahce Istanbul | 2-2 |
| 30/01/25 20:00 | Dynamo Kiew | Rigas Futbola Skola | 1-0 |
| 30/01/25 20:00 | FC Twente Enschede | Besiktas Istanbul | 1-0 |
| 30/01/25 20:00 | AS Roma | Eintracht Frankfurt | 2-0 |
| 30/01/25 20:00 | Glasgow Rangers | Royale Union Saint-Gilloise | 2-1 |
| 30/01/25 20:00 | Slavia Prag | Malmö FF | 2-2 |
| 30/01/25 20:00 | Tottenham Hotspur | IF Elfsborg Boras | 3-0 |
| 30/01/25 20:00 | Maccabi Tel Aviv | FC Porto | 0-1 |
| 30/01/25 20:00 | Ajax Amsterdam | Galatasaray Istanbul | 2-1 |
| 30/01/25 20:00 | Ferencvaros Budapest | AZ Alkmaar | 4-3 |
| 30/01/25 20:00 | Sporting Braga | Lazio Rom | 1-0 |
| 30/01/25 20:00 | Olympiakos Piräus | Qarabag | 3-0 |
| 30/01/25 20:00 | Real Sociedad | PAOK Saloniki | 2-0 |