| Date | Home | Away | Result |
|---|---|---|---|
| 21/01/25 15:30 | Galatasaray Istanbul | Dynamo Kiew | 3-3 |
| 22/01/25 15:30 | Besiktas Istanbul | Athletic Bilbao | 4-1 |
| 23/01/25 17:45 | AZ Alkmaar | AS Roma | 1-0 |
| 23/01/25 17:45 | Malmö FF | FC Twente Enschede | 2-3 |
| 23/01/25 17:45 | FK Bodö/Glimt | Maccabi Tel Aviv | 3-1 |
| 23/01/25 17:45 | Qarabag | FCSB Bukarest | 2-3 |
| 23/01/25 17:45 | Viktoria Plzen | RSC Anderlecht | 2-0 |
| 23/01/25 17:45 | 1899 Hoffenheim | Tottenham Hotspur | 2-3 |
| 23/01/25 17:45 | FC Porto | Olympiakos Piräus | 0-1 |
| 23/01/25 17:45 | Fenerbahce Istanbul | Olympique Lyon | 0-0 |
| 23/01/25 20:00 | Rigas Futbola Skola | Ajax Amsterdam | 1-0 |
| 23/01/25 20:00 | PFC Ludogorets Razgrad | FC Midtjylland | 0-2 |
| 23/01/25 20:00 | Royale Union Saint-Gilloise | Sporting Braga | 2-1 |
| 23/01/25 20:00 | IF Elfsborg Boras | OGC Nice | 1-0 |
| 23/01/25 20:00 | Eintracht Frankfurt | Ferencvaros Budapest | 2-0 |
| 23/01/25 20:00 | Manchester United | Glasgow Rangers | 2-1 |
| 23/01/25 20:00 | Lazio Rom | Real Sociedad | 3-1 |
| 23/01/25 20:00 | PAOK Saloniki | Slavia Prag | 2-0 |