| Date | Home | Away | Result |
|---|---|---|---|
| 28/11/24 17:45 | Lazio Rom | PFC Ludogorets Razgrad | --- |
| 28/11/24 17:45 | Dynamo Kiew | Viktoria Plzen | --- |
| 28/11/24 17:45 | Qarabag | Olympique Lyon | --- |
| 28/11/24 17:45 | Besiktas Istanbul | Maccabi Tel Aviv | --- |
| 28/11/24 17:45 | Rigas Futbola Skola | PAOK Saloniki | --- |
| 28/11/24 17:45 | RSC Anderlecht | FC Porto | --- |
| 28/11/24 17:45 | Athletic Bilbao | IF Elfsborg Boras | --- |
| 28/11/24 17:45 | AZ Alkmaar | Galatasaray Istanbul | --- |
| 28/11/24 20:00 | Slavia Prag | Fenerbahce Istanbul | --- |
| 28/11/24 20:00 | Manchester United | FK Bodö/Glimt | --- |
| 28/11/24 20:00 | Tottenham Hotspur | AS Roma | --- |
| 28/11/24 20:00 | Ferencvaros Budapest | Malmö FF | --- |
| 28/11/24 20:00 | Sporting Braga | 1899 Hoffenheim | --- |
| 28/11/24 20:00 | Real Sociedad | Ajax Amsterdam | --- |
| 28/11/24 20:00 | FC Midtjylland | Eintracht Frankfurt | --- |
| 28/11/24 20:00 | FCSB Bukarest | Olympiakos Piräus | --- |
| 28/11/24 20:00 | OGC Nice | Glasgow Rangers | --- |
| 28/11/24 20:00 | FC Twente Enschede | Royale Union Saint-Gilloise | --- |