| Date | Home | Away | Result |
|---|---|---|---|
| 28/11/24 17:45 | Lazio Rom | PFC Ludogorets Razgrad | 0-0 |
| 28/11/24 17:45 | Dynamo Kiew | Viktoria Plzen | 1-2 |
| 28/11/24 17:45 | Qarabag | Olympique Lyon | 1-4 |
| 28/11/24 17:45 | Besiktas Istanbul | Maccabi Tel Aviv | 1-3 |
| 28/11/24 17:45 | Rigas Futbola Skola | PAOK Saloniki | 0-2 |
| 28/11/24 17:45 | RSC Anderlecht | FC Porto | 2-2 |
| 28/11/24 17:45 | Athletic Bilbao | IF Elfsborg Boras | 3-0 |
| 28/11/24 17:45 | AZ Alkmaar | Galatasaray Istanbul | 1-1 |
| 28/11/24 20:00 | Slavia Prag | Fenerbahce Istanbul | 1-2 |
| 28/11/24 20:00 | Manchester United | FK Bodö/Glimt | 3-2 |
| 28/11/24 20:00 | Tottenham Hotspur | AS Roma | 2-2 |
| 28/11/24 20:00 | Ferencvaros Budapest | Malmö FF | 4-1 |
| 28/11/24 20:00 | Sporting Braga | 1899 Hoffenheim | 3-0 |
| 28/11/24 20:00 | Real Sociedad | Ajax Amsterdam | 2-0 |
| 28/11/24 20:00 | FC Midtjylland | Eintracht Frankfurt | 1-2 |
| 28/11/24 20:00 | FCSB Bukarest | Olympiakos Piräus | 0-0 |
| 28/11/24 20:00 | OGC Nice | Glasgow Rangers | 1-4 |
| 28/11/24 20:00 | FC Twente Enschede | Royale Union Saint-Gilloise | 0-1 |