| Date | Home | Away | Group | Result |
|---|---|---|---|---|
| 05/10/23 17:45 | TSC Backa Topola | Olympiakos Piräus | Group A | 2-2 |
| 05/10/23 17:45 | SC Freiburg | West Ham United | Group A | 1-2 |
| 05/10/23 17:45 | Olympique Marseille | Brighton and Hove Albion | Group B | 2-2 |
| 05/10/23 17:45 | AEK Athens | Ajax Amsterdam | Group B | 1-1 |
| 05/10/23 17:45 | Real Betis Sevilla | Sparta Prag | Group C | 2-1 |
| 05/10/23 17:45 | Aris Limassol | Glasgow Rangers | Group C | 2-1 |
| 05/10/23 17:45 | KS Rakow Czestochowa | SK Sturm Graz | Group D | 0-1 |
| 05/10/23 17:45 | Sporting Lisbon | Atalanta Bergamo | Group D | 1-2 |
| 05/10/23 20:00 | Molde FK | Bayer 04 Leverkusen | Group H | 1-2 |
| 05/10/23 20:00 | BK Häcken | Qarabag | Group H | 0-1 |
| 05/10/23 20:00 | AS Roma | Servette FC Genève | Group G | 4-0 |
| 05/10/23 20:00 | Slavia Prag | Sheriff Tiraspol | Group G | 6-0 |
| 05/10/23 20:00 | Liverpool FC | Royale Union Saint-Gilloise | Group E | 2-0 |
| 05/10/23 20:00 | FC Toulouse | Linzer ASK | Group E | 1-0 |
| 05/10/23 20:00 | FC Villarreal | Stade Rennes | Group F | 1-0 |
| 05/10/23 20:00 | Maccabi Haifa | Panathinaikos Athens | Group F | 0-0 |