| Date | Home | Away | Result |
|---|---|---|---|
| 16/03/23 17:45 | Real Betis Sevilla | Manchester United | 0-1 |
| 16/03/23 17:45 | SC Freiburg | Juventus Turin | 0-2 |
| 16/03/23 17:45 | Fenerbahce Istanbul | FC Sevilla | 1-0 |
| 16/03/23 17:45 | Feyenoord Rotterdam | Schachtjor Donezk | 7-1 |
| 16/03/23 20:00 | Arsenal FC | Sporting Lisbon | 4-6a.PSO |
| 16/03/23 20:00 | Ferencvaros Budapest | Bayer 04 Leverkusen | 0-2 |
| 16/03/23 20:00 | Royale Union Saint-Gilloise | 1. FC Union Berlin | 3-0 |
| 16/03/23 20:00 | Real Sociedad | AS Roma | 0-0 |