| Date | Home | Away | Result |
|---|---|---|---|
| 25/09/24 17:45 | AZ Alkmaar | IF Elfsborg Boras | 3-2 |
| 25/09/24 17:45 | FK Bodö/Glimt | FC Porto | 3-2 |
| 25/09/24 20:00 | RSC Anderlecht | Ferencvaros Budapest | 2-1 |
| 25/09/24 20:00 | OGC Nice | Real Sociedad | 1-1 |
| 25/09/24 20:00 | PFC Ludogorets Razgrad | Slavia Prag | 0-2 |
| 25/09/24 20:00 | Galatasaray Istanbul | PAOK Saloniki | 3-1 |
| 25/09/24 20:00 | FC Midtjylland | 1899 Hoffenheim | 1-1 |
| 25/09/24 20:00 | Dynamo Kiew | Lazio Rom | 0-3 |
| 25/09/24 20:00 | Manchester United | FC Twente Enschede | 1-1 |
| 26/09/24 17:45 | Malmö FF | Glasgow Rangers | 0-2 |
| 26/09/24 17:45 | Fenerbahce Istanbul | Royale Union Saint-Gilloise | 2-1 |
| 26/09/24 20:00 | FCSB Bukarest | Rigas Futbola Skola | 4-1 |
| 26/09/24 20:00 | Olympique Lyon | Olympiakos Piräus | 2-0 |
| 26/09/24 20:00 | AS Roma | Athletic Bilbao | 1-1 |
| 26/09/24 20:00 | Eintracht Frankfurt | Viktoria Plzen | 3-3 |
| 26/09/24 20:00 | Ajax Amsterdam | Besiktas Istanbul | 4-0 |
| 26/09/24 20:00 | Sporting Braga | Maccabi Tel Aviv | 2-1 |
| 26/09/24 20:35 | Tottenham Hotspur | Qarabag | 3-0 |