| Date | Home | Away | Result |
|---|---|---|---|
| 25/09/24 17:45 | AZ Alkmaar | IF Elfsborg Boras | --- |
| 25/09/24 17:45 | FK Bodö/Glimt | FC Porto | --- |
| 25/09/24 20:00 | RSC Anderlecht | Ferencvaros Budapest | --- |
| 25/09/24 20:00 | OGC Nice | Real Sociedad | --- |
| 25/09/24 20:00 | PFC Ludogorets Razgrad | Slavia Prag | --- |
| 25/09/24 20:00 | Galatasaray Istanbul | PAOK Saloniki | --- |
| 25/09/24 20:00 | FC Midtjylland | 1899 Hoffenheim | --- |
| 25/09/24 20:00 | Dynamo Kiew | Lazio Rom | --- |
| 25/09/24 20:00 | Manchester United | FC Twente Enschede | --- |
| 26/09/24 17:45 | Malmö FF | Glasgow Rangers | --- |
| 26/09/24 17:45 | Fenerbahce Istanbul | Royale Union Saint-Gilloise | --- |
| 26/09/24 20:00 | FCSB Bukarest | Rigas Futbola Skola | --- |
| 26/09/24 20:00 | Olympique Lyon | Olympiakos Piräus | --- |
| 26/09/24 20:00 | AS Roma | Athletic Bilbao | --- |
| 26/09/24 20:00 | Eintracht Frankfurt | Viktoria Plzen | --- |
| 26/09/24 20:00 | Tottenham Hotspur | Qarabag | --- |
| 26/09/24 20:00 | Ajax Amsterdam | Besiktas Istanbul | --- |
| 26/09/24 20:00 | Sporting Braga | Maccabi Tel Aviv | --- |