Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 02/02/22 19:00 | 02/02/22 19:00 | Rayo Vallecano | RCD Mallorca | 1-0 | 2 - 4 points |
| 02/02/22 20:00 | 02/02/22 20:00 | FC Valencia | FC Cadiz | 2-1 | 2 - 4 points |
| 03/02/22 19:00 | 03/02/22 19:00 | Real Sociedad | Real Betis Sevilla | 0-4 | 2 - 4 points |
| 03/02/22 20:30 | 03/02/22 20:30 | Athletic Bilbao | Real Madrid | 1-0 | 2 - 4 points |