| Date | Home | Away | Result |
|---|---|---|---|
| 15/01/22 15:00 | RCD Mallorca | Espanyol Barcelona | 2-1 |
| 15/01/22 17:30 | FC Girona | Rayo Vallecano | 1-2 |
| 15/01/22 17:30 | Sporting Gijon | FC Cadiz | 2-4a.PSO |
| 16/01/22 11:00 | Atletico Baleares | FC Valencia | 0-1 |
| 16/01/22 15:00 | Real Betis Sevilla | FC Sevilla | 2-1 |
| 19/01/22 20:00 | Real Sociedad | Atletico Madrid | 2-0 |
| 20/01/22 18:00 | FC Elche | Real Madrid | 1-2a.e.t |
| 20/01/22 20:30 | Athletic Bilbao | FC Barcelona | 3-2a.e.t |