| Date | Home | Away | Result |
|---|---|---|---|
| 26/01/21 18:00 | Real Valladolid | UD Levante | 2-4 |
| 26/01/21 20:00 | Real Betis Sevilla | Real Sociedad | 3-1a.e.t |
| 26/01/21 20:00 | FC Girona | FC Villarreal | 0-1 |
| 27/01/21 18:00 | FC Sevilla | FC Valencia | 3-0 |
| 27/01/21 20:00 | UD Almeria | CA Osasuna | 5-4a.PSO |
| 27/01/21 20:00 | Rayo Vallecano | FC Barcelona | 1-2 |
| 28/01/21 18:00 | CD Artistico Navalcarnero | FC Granada | 0-6 |
| 28/01/21 20:00 | CD Alcoyano | Athletic Bilbao | 1-2 |