| Date | Home | Away | Result |
|---|---|---|---|
| 16/01/21 11:00 | UD Almeria | Deportivo Alaves | 5-0 |
| 16/01/21 11:00 | Deportiva Santa Eulalia del Rio | Real Valladolid | 1-4a.e.t |
| 16/01/21 15:00 | FC Girona | FC Cadiz | 2-0 |
| 16/01/21 17:00 | CF Fuenlabrada | UD Levante | 3-5a.PSO |
| 16/01/21 19:00 | CD Leganes | FC Sevilla | 0-1a.e.t |
| 16/01/21 21:00 | Rayo Vallecano | FC Elche | 2-0 |
| 17/01/21 11:00 | FC Malaga | FC Granada | 1-2 |
| 17/01/21 11:00 | Espanyol Barcelona | CA Osasuna | 0-2 |
| 17/01/21 15:00 | Sporting Gijon | Real Betis Sevilla | 0-2 |
| 17/01/21 15:00 | CD Artistico Navalcarnero | SD Eibar | 3-1 |
| 17/01/21 17:00 | AD Alcorcon | FC Valencia | 0-2 |
| 17/01/21 17:00 | CD Teneriffa | FC Villarreal | 0-1 |
| 20/01/21 18:00 | Cordoba CF | Real Sociedad | 0-2 |
| 20/01/21 20:00 | CD Alcoyano | Real Madrid | 2-1a.e.t |
| 21/01/21 18:00 | UD Ibiza Eivissa | Athletic Bilbao | 1-2 |
| 21/01/21 20:00 | UE Cornella | FC Barcelona | 0-2a.e.t |