| Date | Home | Away | Result |
|---|---|---|---|
| 03/01/23 18:00 | Espanyol Barcelona | Celta Vigo | 3-1a.e.t |
| 03/01/23 18:00 | FC Cartagena | FC Villarreal | 1-5 |
| 03/01/23 18:00 | CF La Nucia | FC Valencia | 0-3 |
| 03/01/23 20:00 | Sporting Gijon | Rayo Vallecano | 2-0 |
| 03/01/23 20:00 | UD Levante | FC Getafe | 3-2 |
| 03/01/23 20:00 | AD Ceuta FC | FC Elche | 1-0 |
| 03/01/23 20:00 | CP Cacereno | Real Madrid | 0-1 |
| 04/01/23 18:00 | Linares Deportivo | FC Sevilla | 0-5 |
| 04/01/23 18:00 | CF Pontevedra | RCD Mallorca | 0-2a.e.t |
| 04/01/23 18:00 | UD Logrones | Real Sociedad | 0-1 |
| 04/01/23 19:00 | Real Oviedo | Atletico Madrid | 0-2 |
| 04/01/23 20:00 | Deportivo Alaves | Real Valladolid | 1-0 |
| 04/01/23 20:00 | CF Intercity | FC Barcelona | 3-4a.e.t |
| 05/01/23 15:00 | Gimnastica Segoviana | CA Osasuna | 1-2a.e.t |
| 05/01/23 15:00 | CD Ibiza Islas Pitiusas | Real Betis Sevilla | 1-4 |
| 05/01/23 20:00 | CD Eldense | Athletic Bilbao | 1-6 |